 Genomic epidemiology plays an ever-increasing role in our understanding of and response to the spread of infectious pathogens. Phylogeography, the reconstruction of the historical location and movement of pathogens, can inform policy decisions related to viral movement among jurisdictions. We assess potential impacts of geographic-based sampling bias on estimated viral locations in the past. This article was authored by Pinyulu, Yixuan Song, Caroline Cullen, and others.