 This research paper examined the development of rice brown oil nanoemulsions using low energy emulsification methods and evaluated their physical stability, irritation potential and moisturizing activity on volunteers with normal and diseased skin types. The nanoemulsion was found to be stable over the time course of the study and had a low irritation potential. When applied to human skin, it improved the skin's moisture and maintained normal skin pH levels. This suggests that the nanoemulsion may be a useful tool to treat skin diseases such as atopic dermatitis and psoriasis. This article was authored by Rochefeliopedroa, Olivero Gustavo C., Vieira Giselle S., and others.