 NED-9 plays a key role in regulating the growth, invasion, and metastasis of non-small cell lung cancer, N-S-C-L-C. In the absence of NED-9, tumors exhibit increased mobility and invasion due to a compensatory rearrangement of intracellular protein signaling pathways and activation of the epithelial mesenchymal transition, EMT. NED-9 may be used as a biomarker of response to chemotherapy. This article was authored by Y. A. Topchew, A. M. Mazatova, M. V. Tycomerova, and others.