 The proposed IDIC microscopy provides a novel solution for achieving isotropic imaging capabilities using a combination of traditional microscopes and metoptics. It utilizes a unique radial shear interferometric pattern to convert the rectilinear shear into rotationally symmetric along radial direction, thus providing single shot isotropic imaging capabilities. This enables edge detection, particle motion tracking, and label-free cellular imaging. This article was authored by Sinway Wang, Hao Wang, Jin Lu Wang, and others.