 Simvastatin is a commonly prescribed drug used to treat high cholesterol levels. It is known to be highly lipophilic, allowing it to easily pass through the blood-brain barrier and potentially treat various brain conditions such as tumors, neurodegenerative disorders, and even Alzheimer's disease. Studies have shown that simvastatin can reduce the risk of developing certain neurodegenerative disorders, while others show that it can induce cell death in brain tumor cells. This review summarizes the potential therapeutic effects of simvastatin on brain complications and discusses the molecular mechanisms involved in these cases. This article was authored by Yenmaivu, Ashraf Katershayib and Majgenrestigar.