 Nodding syndrome, NS, is a type of epilepsy associated with oncocircus associated epilepsy, OE, which is prevalent in areas with high ongoing transmission of oncocirca volvulus. OE, including NS, can be prevented through strengthening oncocircus elimination programs. The presence of tau in post-mortem brains of individuals with OE could be due to neuroinflammation induced by the parasite or a neurotropic virus contained within the worms. OMICS research is needed to investigate this possibility.