 In certain Sankar circumstances, while dealing with informed consent, we have to renew the informed consent as well. Re-consent may be appropriate when the original consent form was invalid or either there has going to be a significant change or substantial change to the research which is important to be informed to the participant. So, sometimes due to the technical feasibility of the research, when we are executing it, we feel that we have to change its methodology or include or exclude any component of it. So, in those situations, there is definitely a change in informed consent and it is necessary to renew it. Research participation may no longer be consistent with the participants in first-hand preferences and they may need to reconsider the decision. May be, participants initially enthusiastically join a long study, for instance, a dataset for which a longitudinal research design is being used and participants have to be a part of the research study for two or three years and have to record all their observations, their milestones, everything. But initially, after two to three months, they feel that they are probably not the feasible participants who can prolong that research and stay with it. So, they can rethink their decision again and we have to take a new participant and we may need to renew it. Then, some examples of the situation that might warrant re-consent include failing to inform the participants about important risk related to the study. Once the study has begun and after that, there is a potential risk that has come in front of it, which was not foreseeable before the study. It is very important to renew the informed consent in that situation and the risk factors to hand they should become the part of the informed consent. Conducting the consent, but participants' decision-making capacity was compromised and they were under pressure. Let's say that when informed consent was filled, at that time, they were students of psychology and they could not call their teacher yes or no and they became a part of a longitudinal study. Later, they felt that it is not possible for them to say yes under pressure but we cannot be a part of the study that for many years we would not generate the data and maybe revisit our decision. Is there any participant who is in a health condition at that time and whose decision power is weak at that time, is in an emotional phase, is in psychological pressure, is in a physical damage and cannot make decisions at that time and that participation of the research comes and later they want to renew it because they feel that they cannot engage more than a certain limit. Then significant changes in research procedure, risk, potential benefit and alternatives. As we move forward in the process of research and we get to see any changes, it is very important that we make those changes a part of our informed consent document. The participant's medical condition worsens or does not respond to the treatment. If we are using a therapy, whether it is medical therapy or psychological therapy or there is an intervention with which the condition is affecting the participant or there is no benefit from it, then it is very important to go here and renew it and revisit it. Using an ineffective representative for a person who is unable to make an informed decision. If we feel that the consent we are taking is an ineffective person, then even in that situation, as we realize, we need to replace it so that we can fill the consent form with concerned and effective person. Research in which pediatric participant will reach adulthood while studying is still in process. Of course, this is a logitcular research in which children grow up and are a part of that research. There can be cohort studies in which children participate from birth to adulthood. To study all that process, the informed consent in the beginning will definitely be an informed permission, but when it comes to the informed consent stage, it will also need to be renewed. Re-consent may be considered appropriate but children reach adulthood so that research participation will reflect their own choices rather than the choices of their partners or their guardians or their parents and anyone who is associated with them. So, such researches that are for a very long time, if they have been given consent form from children, then they should be given consent from them or if they have been given consent from unmarried and after that they have entered a marital relationship and it seems that they cannot participate in that research because of their marital life. So, it is right for them to consult their partners and get some amendments in their consent in the informed consent. Maybe that can be for time change or for some duration. So, anything which is related to the change in participants, you know, with the passage of time in participants, behavior, his choice is appropriate to amendments and it is very important to do that in informed consent and this is called the renewal of informed consent because we can always keep it intact and sustained and it is something which is very much ethical and its practice is not usually done in a lot of researches but we should not undermine its importance because it can be legally challenged.