 The COVID-19 pandemic negatively impacted routine infant vaccination uptake in Quebec, Canada, resulting in a decline in vaccination coverage and children vaccinated on time, particularly during the first months of the pandemic. However, catch-up occurred thereafter and vaccination coverage in affected cohorts was very close to levels of 2019 after a few months of follow-up. Real-time monitoring of childhood vaccinations is essential for other vaccination programs severely affected by the pandemic. This article was authored by Merylou Keely, Thoeba Mansur, Nicholas Brasau, and others.