 This study investigates the role of circular INA, Circa INA, IEB3B, member IS oncogene family, Circa IEB3B, in regulating the phenotypes of Illinois 22-induced HACIAT cells. The results show that Circa IEB3B expression is reduced in psoriatic cutaneous specimens on Illinois 22-treated HACIAT cells, and overexpression of Circa IEB3B inhibits the proliferation, motility, and cell cycle progression while increasing apoptosis. Circa IEB3B acts as a micro-INA 1228-3P, MIR 1228-3P, sponge in HACIAT cells, and MIR 1228-3P overexpression reverses the effects of Circa IEB3B overexpression. Additionally, MIR 1228-3P interacts with phosphatase and tense in homolog, PTEN, and Circa IEB3B sponges MIR 1228-3P to induce PTEN level. Finally, the study concludes that Circa IEB3B suppresses psoriasis progression partly through down-regulating MIR 1228-3P and up-regulating PTEN. This article was authored by Jia Jinglu, Qin Xu, Ying Li, and others. We are article.tv, links in the description below.