 The solubility of hydroxychloroquine sulfide, HCQS, in supercritical carbon dioxide, SCCO2, was measured experimentally at different pressures and temperatures. The experimental results were then compared to the predictions made using several mathematical models. The best-fitting model was determined to be the redigulopotti model, which accurately predicted the solubility of HCQS in SCCO2. Additionally, the total unsolvation in phalpy of HCQS in SCCO2 was calculated using the model constants obtained from the redigulopotti model. This article was authored by Golem Hossen-Sidioufian, Chandra Sikar-Golopotti, Mariam Abab-Mushabadi, and others.