 Cancer remains one of the most serious health problems worldwide, despite advances in treatment options. Research into naturally occurring compounds found in plants, known as phytochemicals, have been used to develop novel anti-cancer drugs. Examples of these compounds include taxile analogues, vinca alkaloids such as vin-christine, vin-blastine, and potaphyla toxin analogues. These compounds can target various molecular pathways involved in cancer growth and progression, including increasing antioxidant status, carcinogen inactivation, inhibition of proliferation, induction of cell cycle arrest and apoptosis, and modulation of the immune system. This review summarizes recent trends and gaps in phytochemical-based anti-cancer drug discovery, focusing on the evaluation of anti-cancer phytochemicals at both preclinical and clinical levels. This article was authored by Amit S. Jodhari, Pallavi C. Mandave, Manasi Deshpande, and others. We are article.tv, links in the description below.