 This paper examines the phenomenon of T cell exhaustion, Tx, in ovarian cancer patients. It uses single cell RNA sequencing to identify genetic markers associated with Tx, as well as to explore differences in clinical outcomes between patients with different levels of Tx. The authors find that patients with lower levels of Tx have better survival rates, higher tumor mutational loads, and more immune cell infiltration than those with higher levels of Tx. Additionally, they show that certain genes related to Tx are differentially expressed in patients with different levels of Tx. This research provides important insights into how Tx affects ovarian cancer patients and could help inform future treatments. This article was authored by Kamyayuan, Songyun Zhao, Bichinyi, and others.