 This study used a combination of design of experiments, DOE, and physiologically based biopharmaceutical modeling, PBBM, to develop a predictive dissolution method for desgenophaxeniar tablets. The study found that the superficial area slash volume ratio, SA slash V, of the tablet had a significant effect on the rate of drug release. Additionally, the dissolution test conditions of 900 milliliters of 0.9 percent sodium chloride solution and paddle at 50 rpm with a sinker were found to be biopredictive, allowing for the demonstration of virtual bioequivalence between three different products despite their differing release patterns. This approach provides valuable information that can be used to optimize the development of a predictive dissolution method for desgenophaxeniar tablets. This article was authored by Gustavo Viano Carpito, Marcello Dutra Duque, Michelle Giorgisa, and others.