 This study found that downregulation of Chlodin-5 in esophageal squamous cell cosonoma, ESCC, tissues was associated with poor radiotherapy response and prognosis. It also demonstrated that Chlodin-5 downregulation promoted ESCC malignant progression and radio resistance through Becclin-1 autophagy activation. These results suggest that Chlodin-5 could be a potential biomarker for predicting radiotherapy response and patient outcome in ESCC. This article was authored by Shan Huang, Jiayi Zhong, Yi Li, and others.