 A novel polymer containing hydrophobic ferrocene units and thio-ketal bonds in the main chain is described that delivers a prodrug of oxalipitin and artesanate to cancer cells, generating abundant reactive oxygen species, ROS, to kill cancers as nanobomb for cancer therapy. The ROS-generated in situ triggered the breakdown of thio-ketal bonds in the polymer, resulting in biodegradation of the polymer. Furthermore, nanobomb facilitates the maturation of dendritic cells and promotes the activation of anti-tumor immunity by enhancing immunogenic cell death effect. Metabolomics analysis reveals a decrease in glutamine in nanobomb-treated cancer cells, resulting in upregulation of programmed death ligand 1, PDL1. Enhanced tumor inhibitory effects are demonstrated when using nanobombig combined with anti-PDL1 therapy. The nanosystem offers a rational design of an efficient chemoimmunotherapy regimen to promote anti-tumor immunity by improving tumor immunogenicity, addressing the key challenges cancer immunotherapy faced.