 Abstract CU-based nano-catalysts are the foundation of many industrial catalytic processes. Strengthening their catalytic stability and activity has been a long-standing challenge. In this study, the high entropy principle was used to modify the structure of CU-based nano-catalysts, resulting in the creation of two DCU-2ZN1R0.5CE5ZR0.5-Ox. This material exhibited improved sintering resistance, increased CO2 hydrogenation activity, and a record photothermal CO2 hydrogenation efficiency. These results demonstrate the potential of high entropy materials to improve the performance of CU-based nano-catalysts. This article was authored by Ye Guangli, Zanhua Bai, Dacha Yuan, and others.