 Los Angeles is now the latest city to be placed under martial law. All residents are required to report to... Again, maybe stepping away from the last of us for a minute and let's talk about the real world and vaccine development. How do we decide which basket we put our eggs in? Maybe I think an answer to decide stuff. Where do we spend the money, I suppose? What sort of thoughts go into that? So, I mean, the most obvious starting point would think, where's the biggest burden of disease at the moment? Something like, say, smallpox was an amazing target to go for vaccination in an eradication campaign because it was killing a million or put more people a year at a time. They're aware that because of... there weren't any sort of non-human reservoirs for it. So, if you could eliminate it in human beings, you get rid of it from the world altogether. So, the fact that it was killing a lot of people, also it was a good target because it was possible to eradicate it altogether. That made it a superb target. In other sorts of cases, you can have something with a very high rate of deaths coming from it, something I'd say malaria, where it looks like a good target on paper, but there's a question of, well, if it's going to be carried by mosquitoes, if it's going to be stagnant water, whether mosquitoes can breed, is it really going to be possible to eradicate it as the Gates Foundation is? It kind of touts us as a possibility, but they haven't fully committed to it. Certainly, if you could do it, it would be fantastic. It looks like, well, it would be an amazing thing to do, and certainly the health benefits would be extraordinary. So, that's almost like the big ticket stuff, but going down the list, effectively what you want to know is, how deadly is the disease, how effective will the vaccine be, how long will it last? It's not complicated to do, but you can do mathematical modelling, effectively to ask the health question, well, how expensive is it to save a life through vaccinating people for this disease compared to anything else that we can do? And in terms of expense, I think that's an important one. I think smallpox is a good example, because the vaccine was relatively inexpensive. They managed to get the cost right down, and also you could tell if someone was infected or not. It was very clear from looking at them, whereas this case, it's not so clear in the first instance. It's a very important thing for these things. Again, certainly to roll out vaccines to countries that really, I mean, we call them low- and middle-income countries. What's the magic number, do you think, for the cost of a vaccine for it to be used and useful for everyone? Less than a dollar? Sorry, I'm not sure about that. No, okay, alright. I think a lot of it depends on who's going to be paying for it, so that something like, say, the polio vaccination campaign has been supported by the Rotary Club for ages, and people, they've been fundraising for this for many, many years. There's a global alliance for vaccines. Other people where they've received big donations, whether from governments or from private foundations. And at that point, it doesn't quite matter so much about what the cost is per vaccine. If the country where the vaccine is going to be deployed is not necessarily paying for it. So at a certain point, it has to be, well, it has to be cost-effective enough that somebody's willing to stump up the money. Ultimately, sadly, it comes down to cash. I'd really like my rifle back now. No, you have your pistol. I hope you know how to use that thing.