 The study investigates the effects of 36 naturally occurring flavonoids on nitric oxide, NO, production, in macrophages, exposed to an inflammatory stimulus. The results show that 8-flavons and related compounds inhibit INOS protein and mRNA expression, as well as NO production, by inhibiting the activation of nuclear factor B, NFB, and signal transducer and activator of transcription 1 and stat 1. These findings partially explain the pharmacological efficacy of flavonoids, as anti-inflammatory compounds. This article was authored by Marie Hamelainin, Brinana Minin, Piavoella, and others.