 This study found that intraarticular polynucleotide, IAPN, injection had comparable efficacy and safety to high molecular weight hyaluronic acid, HMWHA, when used for treating the osteoarthritis OA. Both treatments resulted in decreased pain levels and improved function over time. However, IAPN injection was associated with fewer side effects than HMWHA. This article was authored by Tai Wu Kim, Moon Jong Chung, Chan Yeop Shin, and others.