 Dutch and muscular dystrophy, DMD, is a genetic disorder that causes progressive weakness and wasting of the muscles. It is caused by mutations in the gene that codes for dystrophin, which is a protein found in muscle fibers. The disease is characterized by inflammation of the muscles, which is thought to be driven by cytokines and chemokines. These molecules are involved in cell signaling and communication, and can have both positive and negative effects on muscle health. Understanding how these molecules work in DMD may lead to new treatments for the disease. This article was authored by Belda Popper and Jan El de Bleeker.