 Nonsteroidal anti-inflammatory drugs, NSAIDs, are commonly prescribed medications used to treat pain and inflammation in patients with arthritis or other conditions. They can also be taken over the counter by many people to relieve minor aches and pains. Despite their widespread use, there have been concerns about potential side effects from taking these drugs. The most common side effects include stomach irritation, ulcers, bleeding, kidney damage, and heart problems. Some NSAIDs are even known to cause serious life-threatening complications such as stroke and heart attack. Recent studies have shown that certain NSAIDs may actually be beneficial for the heart, however, and may help protect against heart disease. This article was authored by Sam Harreferush, Waheed Iskar, and Fakretin Jamali.