 Antimicrobial peptide-based biomaterials are promising candidates for the treatment of bacterial infections due to their ability to target specific pathogens without harming healthy cells. This review summarizes the current status of research into these materials, focusing on their use in animal models of abdominal, skin, and eye infections. The authors hope that this review will encourage further innovation in the field and help expedite the commercialization of these materials. This article was authored by Guo Yuli, Zhenhun Lai, and Anshan Shan.