 gelatin has been widely used in pharmaceutical formulations cell cultures and tissue engineering due to its excellent biocompatibility ease of processing and low cost. In the past decade, gelatin has been extensively investigated for various ocular applications such as cell sheet carriers, bio adhesives and bio artificial grafts. These applications require distinct physical, chemical and biological properties which has led to the development of modified gelatin-based materials. Crosslinking gelatin alone or in combination with natural or synthetic biopolymers has resulted in a variety of scaffolds that are suitable for ocular applications. This review discusses the methods used to crosslink gelatin-based materials and their application in ocular tissue engineering. It also highlights future opportunities for gelatin-based materials in ophthalmology. This article was authored by James B. Rose, Satimio Pacelli, Alicia J. L. Hodge and others. We are article.tv, links in the description below.