 Global health research is currently plagued by inequalities due to the unequal distribution of resources between high-income countries, HICs, and low- and middle-income countries, LMIX. Donor and funder support is needed to ensure greater equity in global health research, including through direct funding to LMIC researchers and direct funding to build local LMIC-based, led, and run knowledge infrastructures. This article was authored by Esmita Charani, Seya Bimbola, Madhukarpai, and others.