 The study shows that CRF receptor type 2, CRF2, and its high affinity ligand, Eurocortin 1, UCN1, are key mediators of the endoplasmic reticulum, ER, stress response in a murine model of acute pancreatic inflammation. UCN1 is expressed in NOVO in assina cells of male but not female weight mice during acute inflammation. CHR2 mice of both sexes show exacerbated assina cell inflammation and necrosis, with markedly distorted ER structure in males. Damage in ER structure is accompanied by increased ubiquitination, PIF2, and mistargeted localization of vimentin. Exogenous UCN1 rescues many aspects of histological damage and cellular stress response in male weight and CHR2 mice but not in females, suggesting that specific cellular pathways involved in coping and resolution are distinct to each sex. This article was authored by Eric Kubit, Shilpi Mahajung, Minit Leo, and others. We are article.tv, links in the description below.