 In this study, researchers examined the relationship between serum lipids and cholesterol cellular metabolism in lung cancer patients. They found that triglyceride levels were positively associated with body mass index, BMI, while HDL cholesterol was negatively associated with BMI, seroactive protein, CRP, and overall survival. Additionally, they observed that total cholesterol was negatively associated with tumor size, serum CRP, and overall survival. Furthermore, they found that HMGCR and ACAT1 were upregulated, while ABCA1 was down-regulated in the tumoral region of their lung cancer cohort, suggesting that cholesterol-disregulated cellular export may play a role in lung cancer development and progression. This article was authored by Philip Hartman, Dennis I. Truffer, Kottier-Hohenberger, and others.