 The Institute for Systems Biology, ISB, has created a cross-disciplinary platform and culture in which biology drives technology drives computation to study complex biological systems. This systems approach on disease has led to the discipline of systems medicine, which has united genomics and genetics through family genomics and made blood a window into health and disease. The convergence of patient-activated social networks, big data, and their analytics and systems medicine has led to P4 Medicine, which is predictive, preventive, personalized, and participatory. P4 Medicine will improve healthcare, reduce the cost of healthcare, and stimulate innovation and new company creation. This integrative, cross-disciplinary, and systems-driven approach can also be applied to other challenges plaguing our planet, such as energy, environment, nutrition, and agriculture. This article was authored by Lee Roy Hood. We are article.tv, links in the description below.