 In this study, it was found that major depressive disorder, MDD, patients with comorbid glucose metabolism abnormalities, had a higher prevalence of abnormal lipid metabolism compared to those without such abnormalities. Furthermore, thyroid hormone function and BMI were identified as independent risk factors for abnormal lipid metabolism in MDD patients with comorbid glucose metabolism abnormalities. This article was authored by Kuan Fengzhu, Guo Junjiang, Xiao Yilang, and others.