 Point-of-care devices are changing the way healthcare can be delivered. However, few devices actually make it into clinical use. This is due to many technological challenges, such as making the devices accurate, robust, portable, and easy to use. Dr. Weisslater and his research team at Massachusetts General Hospital have adapted magnetic resonance imaging technology to overcome many of these challenges. They have produced a miniaturized MR point-of-care device that is capable of analyzing cells, proteins, nucleic acids, viruses, and bacteria, a broad range of clinically relevant substances. And they are able to achieve this faster and more accurately than conventional methods. Dr. Weisslater's team has demonstrated they are able to detect multiple biomarkers with a device to allow for molecular profiling of cells and tissues. This can enable accurate diagnosis of disease, guide therapeutic interventions, and ultimately facilitate the application of personalized medicine. We recently developed a miniaturized micro-NMR technology in the laboratory, which has been used in very exciting, different translational applications. It has unprecedented sensitivity since there are usually no magnetic signals present within the body. And in addition to that, it has built-in amplification strategies that we harness for very sensitive detection. We have used this new micro-NMR technology in a number of different biological and translational applications. For example, we have used it to detect rare cancer cells. We have used it to detect very few bacteria during bacterial infections. We're using it in new ways to see if treatments fail or actually work in individual patients. And we use it to detect exosomes, which are tiny little vesicles shed off by cancer cells in the human body. Its key advantages is that one does not need to purify biological samples. It is also much more sensitive than many other optical technologies out there. Initial studies using cells from fine needle aspirates of intra-abdominal lesions have shown that Dr. Weisslater's micro-NMR device provides superior accuracy in diagnosing cancer as compared to standard biopsy. In addition to being more accurate, his approach is much more rapid than traditional biopsies and is far less invasive, enabling repeat sampling of tumors. Overall, it's a huge step forward in developing diagnostic tests for personalized medicine.