 The endoplasmic reticulum, ER, is an organelle of nucleated cells that produces proteins, lipids, and oligosaccharides. Upon induction of unfolded protein responses, UPR, its volume and activity increase. When the ER is stressed, it activates ER-phagy programs to reduce its size. The nuclear envelope, NE, is composed of two juxtaposed lipid bilayers, the inner and outer nuclear membranes, FI-NM and O-NM, respectively. During homeostasis, the mammalian ER expands, resulting in the disassembly of the linked complexes connecting I-NM and O-NM. This process is reversed when the ER returns to normal functioning, through the autophagic removal of the NE, which involves the LC3 lipidation machinery, the autophagy receptor SeX-62, and the capture of O-NM, derived vesicles by degradative LAMP-1, I-B7 positive endolysosomes. This article was authored by Marika Kekachinska, Juliette Federie, Carmela Golly, and others. We are article.tv, links in the description below.