 Continuous monitoring of SARS-CoV-2 variant properties is important for public health planning. Here, the authors use data from the United States and show that Armacran BA.45 subvariants, which became dominant in mid-2022, have stronger immune escape properties, but are no more severe than the previously dominant BA.2. This article was authored by Joseph A. Lunard, Venice Hong, Jennifer S. Kim, and others.