 The artificial kidney, aka, is a type of renal replacement therapy that uses a membrane to separate the failing kidney's function from the patient's bloodstream. This allows for the treatment of patients with end-stage renal disease. As the technology has evolved, the use of high-flux hemodialysis, HFHD, has become more commonplace, which involves the use of ultrafiltration membranes with higher convection permeability. These membranes can cause increased shear stress near them, which can be harmful to the patient. To address this issue, researchers have created an artificial kidney surrogate consisting of two chambers separated by an ultrafiltration membrane. This model was designed to mimic the blood flow rates and membrane fluid removal rates of HFHD, allowing for the study of the effects of these parameters on shear stress. It was found that the pressure drop of the system increases as the blood flow rate increases, and that the pressure drop is significantly greater for the permeable membrane than it is for the impermeable wall. This article was authored by Matilda De Pascol, Monica Fahia, Christiana Boy, and others. We are article.tv, links in the description below.