 In recent years, there has been significant progress in understanding how the hepatic microenvironment can be manipulated to treat liver cancer and fibrosis. This review summarizes the latest developments in nanotherapies designed to remodel the hepatic microenvironment, including novel strategies for regulating immune suppression, metabolism and vascular remodeling. Additionally, new approaches to targeting antigen-presenting cells and T-cells are being explored to prevent liver fibrosis. This article was authored by Xingtao Zhao, Felix Kwameyameva, Sinyan Xue and others.