 Abstract virus-like particles, VLPs, are virus-derived structures composed of one or more different molecules that can self-assemble, mimicking the form and size of a virus particle without containing any genetic material. They can be produced using various expression systems and then reconstituted into their original shape. VLPs are becoming increasingly popular in the field of preventative medicine due to their ability to elicit both antibody and cell mediated immunity. Additionally, VLPs are being used as vaccines against various infectious agents, with the most recent example being the SARS-CoV-2 vaccine. Despite their success, there are still many challenges to overcome before VLPs become widely accepted. These include the difficulty of producing large quantities of VLPs, the potential for side effects, and the need for further research on how best to activate the immune system. Nonetheless, VLPs show great promise as a new generation of vaccines and therapeutics. This article was authored by Sargi Nuri, Hara Barulalam, Sekia Sadatozini, and others. We are article.tv, links in the description below.