 The PI3KAKTMTO or Signalling Pathway is a complex network of proteins involved in various cellular processes, including cell growth, differentiation, and survival. It has been implicated in several diseases, including ischemic brain injury, neurodegenerative disorders, and cancer. Several drugs targeting this pathway have shown promise in pre-clinical studies, and some have been tested in clinical trials for treating hematologic malignancies and solid tumours. This article was authored by Fei Xu, Lysin Na, Yan Fei Li, and others.