 This study found that single doses of bitter melon fruit up to 4,000 milligrams per kilogram had no adverse effects on mouse kidney function or structure. However, when administered over a period of seven days, higher dosages of bitter melon caused a slight increase in blood urea nitrogen levels and creatinine levels, indicating possible kidney damage. Further research is needed to determine the optimal dosage of bitter melon for safe use in humans. This article was authored by Saeed Mardani, Hamid Nasri, Shabnam Haji and others.