 This study compared the expression of the cysteine-rich 61-Seer 61 protein in the urine of early onset preeclampsia, PE, patients with that of the urine of normo-tensive healthy pregnant women. The results showed that the urine Seer 61 protein levels were significantly higher in the early onset PE group, 922.6 plus or minus 1263.1 PG slash ML, than those of the control group, 499.2 plus or minus 270.2 PG slash ML, P less than 0.001. These findings suggest that Seer 61 may be a potential biomarker for early detection of PE. This article was authored by Mustafa Biram and Suleiman Semilaglak.