 Cardiorenal syndrome, CRS, is a complex interplay between the heart and kidneys that occurs when one organ is affected by another's dysfunction. It can be divided into five distinct subtypes depending on the cause of the dysfunction. Type 1 CRS is caused by acute kidney injury due to cardiac dysfunction, while types 2 and 3 are caused by cardiac dysfunction due to acute kidney injury. Types 4 and 5 are caused by chronic kidney disease leading to cardiac dysfunction. Pediatric populations have been found to be at higher risk of developing CRS than adult populations. Common comorbidities seen in pediatric CRS include hematologic, oncologic, cardiology-related side effects, muscular dystrophy, and pneumonia bronchiolitis. Treatment of CRS typically includes diuresis, extracorporeal fluid removal, and treatment of the underlying etiology and comorbidities. This article was authored by Subbal Kumar Pradhan, Harsha Agnani, Rama Safadi, and others. We are article.tv. Links in the description below.