 This study systematically analyzes research using the health belief model, HBM, as a theoretical basis to examine the influence of HBM constructs on COVID-19 vaccine hesitancy, finding that perceived barriers and benefits were significantly associated with vaccine hesitancy. The prevalence of vaccine hesitancy was 33.23%, and other HBM constructs such as perceived susceptibility, cues to action, perceived severity, and self-efficacy were inversely associated with vaccine hesitancy. Gender, education, age, geographical locations, occupation, income, employment, marital status, race, ethnicity, knowledge of COVID-19, prior diagnosis of COVID-19, history of flu vaccination, religion, nationality, and political affiliation were also found to be modifying factors that influenced vaccine hesitancy. Overall, the study shows that HBM is useful in predicting COVID-19 vaccine hesitancy. This article was authored by Yambi Limbu, Rajesh K. Gautam, and Longfam. We are article.tv, links in the description below.