Final stages of HIV assembly





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Published on May 16, 2014

This 10-second movie shows the role of a protein named ALIX (labeled green with a fluorescent protein) as it is gets involved in the formation or "budding" of two new human immunodeficiency virus (HIV) particles out of a human cell. The new HIV particles are made mostly of a protein named Gag. The movie shows two places (red) where Gag is assembling to form HIV particles. It shows that green-labeled ALIX proteins get involved late in the process when they bind in a blaze of green color to newly forming virus particles (expanding red spots). That is the key finding of a new University of Utah study led by virologist-physicist Saveez Saffarian and physics doctoral student Pei-I Ku.

See University of Utah news release at:

Credit: Pei-I Ku, University of Utah.

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