 Obesity has been linked to an increased risk of developing certain cancers, such as endometrial, esophageal adenocusinoma, colorectal, postmenopausal breast, prostate, and renal, as well as less common cancers like leukemia, non-Hodgkin's lymphoma, multiple myeloma, malignant melanoma, and thyroid tumours. Insulin, insulin-like growth factor I, sex steroids, and adipokines are all thought to play a role in this connection. Chronic inflammation, oxidative stress, cross-talk between tumour cells and surrounding adipocytes, migrating adipose stromal cells, obesity-induced hypoxia, shared genetic susceptibility, and the functional defeat of immune function are all believed to contribute to the development of these cancers. This article was authored by Giovanni de Pergola and Franco Silvestri's.