 This study examined the impact of sex and age on the development of cardiovascular disease in stroke prone, spontaneously hypertensive rats, SHRSBs. It found that males were more likely to develop cardiovascular disease than females and that age was also a factor in the development of cardiovascular disease. Additionally, males showed greater levels of renal and cardiac fibrosis, as well as cellulose in essence when compared to females. This suggests that sex plays a significant role in the development of cardiovascular disease and that age can exacerbate the effects of sex on the development of cardiovascular disease. This article was authored by Anisa Ansari, Sarah L. Walton, and Kate M. Denton.