 Polymeric micelles are self-assembling nanoconstructs made from amphiphilic copolymers with a core shell structure that have been used for drug and nucleic acid delivery. They have several favorable properties including the ability to solubilize poorly soluble drugs, biocompatibility, stability and targeting capabilities. Recent advances in the development of multifunctional polymeric micelles have shown promise for improving the efficacy of current treatments including the delivery of therapeutic genes, antibodies and small interfering RNA, CERNA. Lipid-based micelles are also a promising vehicle for CERNA and drug delivery due to their potential for safe, effective and clinically suitable use.