 TRPM7 is a protein involved in many biological processes such as embryonic development, immunity, cell movement, proliferation, and differentiation. It is also implicated in several diseases including cancer and neurological disorders. Recently, it was discovered that TRPM7 can be activated by a gain of function mutation or by the drug Naltribon, which causes the channel to open up and allow more calcium into cells. This discovery provides insight into how TRPM7 works and could lead to the development of drugs that target this channel. This article was authored by Kirill Deena Desdin, Leona Kharia, Shomali Narangada, and others.