 Hepatocellular carcinoma, HCC, is one of the most common types of liver cancer, with over 90% of cases being caused by chronic liver disease. Chemotherapy and immunotherapy are the primary treatments for HCC, but they often come with serious side effects due to their systemic nature. Localized chemotherapy has been shown to be more effective at reducing these side effects, as it delivers the drugs directly to the tumor site. One way to do this is through the use of biodegradable hydrogels, which can release the drugs slowly over time. These hydrogels have been found to be particularly effective in treating HCC, as they allow for greater control over the amount of drug released and the rate at which it is released. Additionally, they can be designed to respond to various environmental factors, such as temperature or pH changes, making them even more effective. This article was authored by Bihari Farisadi Far, Alia Tarapouris Fahani, Alma's Nazarian, and others. We are article.tv, links in the description below.