 Anecdotal reports suggest potential severity and outcome differences between sexes following infection by SARS-CoV-2. Here, the authors perform meta-analyses of more than 3 million cases collected from global public data to demonstrate that male patients with COVID-19 are three times more likely to require intensive care and have 40% higher death rate. This article was authored by Hannah Peckham, Nina M. de Gruta, Charles Reign, and others.