 This article discusses the use of chemicals in various industries and their negative impact on human health. The modern world aims to replace these harmful chemicals with eco-friendly products, such as enzymatic processes. Microbial proteases are essential enzymes used in different corporate sectors, including textile, detergent, leather, feed, waste and others. Proteases have both physiological and commercial roles and are found ubiquitously in plants, animals and microbes. Bacillus sp is the most commercially exploited microbe for proteases. Researchers are looking for ways to improve the stability, specificity and substrate tolerance of microbial proteases. The article compares different proteases and highlights the challenges faced during production and application at the industrial level. Addressing these issues will enable the promotion of microbial proteases economically and commercially worldwide. This article was authored by Abdul Razak, Saadia Shamsi, Arfinale and others. We are article.tv. Links in the description below.