 Glyoblastoma multiforme, GBM, is a type of aggressive brain cancer that is difficult to treat due to its high rate of recurrence and resistance to traditional therapies. New research has identified several potential targets for developing more effective treatments, including targeting the tumor's ability to form blood vessels, induce cell death, and regulate autophagy. Additionally, novel chemotherapy agents and drug combinations have been developed which show promise in improving patient outcomes. This article was authored by Julian P. Ramirez, Jessica L. Weatherby, Richard T. Wheelhouse, and others.