 The Clinical and Translational Science Award, CTSA, program has been instrumental in developing informatics infrastructures to support clinical and translational research during the COVID-19 pandemic. These efforts have included increased reliance on EHR data, development of data capture, standards, interchange, and sharing policies, and the creation of a National Clinical Data repository in the National COVID-19 cohort collaborative, N3C. Based on survey data from CTSA sites, seven recommendations are made for informatics and public health investments, and further study to support clinical and translational research in the post-COVID-19 era.