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Uploaded on Feb 7, 2012

Left panel: Random snapshots of experimental cryo-electron micrographs of closed wild-type chaperonin Methanococcus maripaludis obtained at a mean electron count of 20/Å2.

Center panel: Tilt-series of class-averaged images with orientations determined by the manifold embedding. The black boxes indicate no images in that orientation class.

Right panel: Tilt-series of images generated from the manifold with orientations determined by manifold embedding.

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